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This phenomena relates to the redundancy of biological systems which are to ensure that the system retains functioning inspite of the perturbations.
Similar(59)
So, if ascorbic acid was widely available in the human primitive diet, then selection to retain functioning GULO would have been relaxed (Lahti et al. 2009).
However, some variants retained functioning similar to the wild type.
In case of type 2C, mutant pVHL retains function as E3 ubiquitin ligase to HIFs which induce angiogenic factors and stimulate glucose metabolism in cancer cells.
This study explains why the S236A mutation retains function, but it still does not account for the conservation of serine in this position in the myosin superfamily.
"The premise of orthopedics is to restore alignment so you can retain function," says Lieberman.
The super stability with retained function results from the "hydrophobic effect" of supramolecular self-assembly of peptides and drugs.
And in both the mind-door and five-sense door processes, when the retaining function ceases, the mind reenters its inactive mode.
Implants maintain osseointegration with the inside of the bone over long periods of time, and mechanical factors are important for retaining function [1].
Her spine was crushed, and while she retained function in her arms, she has none in her lower limbs.
These multiple structural requirements limit the opportunities for creation of mutations that lack diphthamide while retaining function in protein synthesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com