Exact(1)
HEI-OC1 cells, an auditory hair cell line that retains cell division activity [ 25], were kindly donated by Dr. Federico Kalinec (House Ear Institute, Los Angeles, CA, USA).
Similar(59)
Therefore, it seems likely that the differences in transcript profiles are age-related and reflect molecular genetic modifications that are retained during cell division.
The term "epigenetics" was initially reserved for mechanisms by which phenotypic state, as determined by differential gene expression, could be stably retained through cell division by non-genetic factors.
Epigenetics involves information retained during cell division other than DNA sequence per se, and both DNA methylation and post-translational modifications of histones are fundamental in understanding normal development and disease [ 1- 3].
Intriguingly, this interplay is distinct for individual PQC factors within the same cell, as thermal stress induces localization of Hsp104, Ssa1, and Sis1 to cytoplasmic foci, but only Hsp104 is asymmetrically retained upon cell division, suggesting an additional point of proteostasis regulation.
Label retaining cell.
By integrating into the host genome, the construct is retained through cell divisions and can be stably expressed for an indefinite period of time.
The parental cell wall is partially retained after this cell division and participates in the formation of the thallus.
The authors convincingly demonstrate that heat-induced aggregates of proteins other than Sup35 asymmetrically retain Hsp104 during cell division, in a process that is dependent of the enzymatic activity of Hsp104, and thereby increase Hsp104 concentration in mother cells to a level that allows Sup35 disaggregation and prion curing during recovery from heat stress.
These cells are similar to the chordate radial glia in a number of morphological and immunocytochemical characteristics [ 19, 21, 22, 24, 25] and, most importantly, also retain capacity of cell division in adult individuals, suggesting that they can be possibly involved in adult neurogenesis in these marine invertebrate deuterostomes [ 22].
The percentage of label-retaining 1s/2s cells in contact with ECM was higher than those which retained partial label indicating cell division.
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