He also called for the use of certain critical antibiotics, regarded as the last line of defence against devastating human illnesses, to be kept from routine use in animals in order to retain their efficacy.
The way to ensure that antibiotics retain their efficacy against disease is to know exactly how and in what quantities they are being administered and to eliminate unnecessary usage.
Both therapeutics released from the composite coating retained their efficacy over their established release timeframes.
Both growth factors retained their efficacy, as quantified with relevant in vitro assays.
Although current formulations of amoxicillin and amoxicillin/clavulanate have retained their efficacy against many, but not all, penicillin‐nonsusceptible Streptococcus pneumoniae, additional coverage is required to address the growing problem of drug‐resistant strains.
For many such patients stable doses of benzodiazepines retain their efficacy over several years.
Western blotting of cell lysates 72 h post-transfection confirmed that CtBP- and p53-targetting siRNAs retain their efficacy when applied in combination and with a chemotherapeutic agent.
Recent subgroup analysis showed marginal survival benefit from oxaliplatin as adjuvant treatment of patients aged ≥70, whereas oral fluoropyrimidines retained their efficacy [ 18, 20].
An interesting finding is that 50% of our cases responded well to cefazolin/ceftazidime, although these antibiotics are reported to have poor efficacy against anaerobes, while aminoglycosides retain their efficacy because of earlier use during disease courses, as stated above [ 5, 20, 23].
We have shown that the gatekeeper valine to methionine substitutions in FGFR1 and FGFR3 resulted in reduction of sensitivity to selective inhibitors PD17307 and AZD4547; two other tested inhibitors, AP24534 and TKI258, retained their efficacy (Fig. 1, Fig. 2, Fig. 4, Table 1).
