Their data demonstrated that PC3 cells have retained the cellular machinery required to respond to the activated androgen receptor.
The use of paraffin tissue preparations coupled to Methacarn fixation provided rice root tissues that satisfactorily retain the cellular morphology.
Therefore, we postulated that cancer cell lines may also retain the cellular hierarchy characteristic of primary breast tumors.
We show that it is the N-terminus of FTO that binds to XPO2, and that the N-terminus of FTO in isolation retains the cellular localization of full-length FTO.
Identifying variants of obatoclax lacking these activities may yield important new second-generation Mcl-1 lead inhibitors [ 34] while retaining the attractive cellular and in vivo activities of this class of Mcl-1 antagonist.
Current liver bioengineering strategies are based on retaining the actual architecture, cellular composition, ECM composition, mechanics and physicochemical gradients in the liver.
Therefore, cancer cells, though differing in 'self', have the ability to retain the same cellular capacities that are exhibited by all other cells in any tissue ecology.
In contrast, PDXs retain the morphology, cellular heterogeneity, and molecular profiles of the original patient tumors [ 1, 4- 9, 20- 22], thereby being relevant preclinical models to identify effective therapeutic regimens that can be translated into clinical practice.
The implication here is that LUCA possessed a nucleus, and that this was lost from the archaea and bacteria, with a handful of lineages perhaps retaining this cellular architecture (notably the Planctomycetes).
The lipid fraction was recovered in Folch solvent, the solvent was evaporated, and the radioactivity retained in the cellular lipid was determined by scintillation counting.
