This similarity could indicate that proteins with functions ancestral to the Nematoda have diverged to represent lineage-specific functions, while retaining functions of ancestral importance (Table S6).
Enteral nutrition is required in all patients who are unable to cover their energetic and nutritional requirements by means of normal ingestion despite, at least partially, retained function of the gastrointestinal tract.
In light of this intriguing hypothesis, it will be very interesting to ask what is the retained function of the zebrafish barhl1.2 in the RGC lineage and in relation to atoh7.
Recruitment of newly originated genes at early stages of developmental might allow evolution of specific phenotypes, while conserved genes retain function for the conserved core of development.
In all cases, the obtained conjugates retained functions of individual modules.
There are many reasons why older adults lose lower limb function including osteoarthritis and falls, but physical activity is the most effective way of retaining function.
The I464A and R466A mutants retain function, though mutation of D469 to alanine inactivates the protein, both in terms of checkpoint function and catalytic activity.
While mice and other mammals retain function and expression of almost all OLFRs, the majority of these are pseudogenized in humans [ 16].
This phenomena relates to the redundancy of biological systems which are to ensure that the system retains functioning inspite of the perturbations.
Indeed, immunoblots from mitochondria-containing pellet fractions showed identical patterns of mitochondrial Smac loss between Cerulean- or C-XIAP-C-expressing cells, confirming that the Smac-retaining function of XIAP is situated downstream of MOMP.
Regions of GFP that tolerate the introduction of circular permutation are more likely to accept the addition of another protein while retaining the function of both proteins.
