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In summary, the hydrogel substrate identified, poly AEtMA-Cl-co-DEAA) cross-linked with MBA, poly AEtMA-Cl-co-DEAAmaintained over 10 poly AEtMA-Cl-co-DEAAia thermo-modulation), with the cells retaining expoly AEtMA-Cl-co-DEAAiated markers and lineage potency.
A fact supported by the finding that kidney epithelium that lacks Foxi1 while retaining expression of carbonic anhydrase II, a marker for intercalated cells, have no detectable levels of neither A1 nor E2 mRNA (Fig. 8).
Indeed, all tumors that arose in the MMTV-Cre/MMTV-PyVmt;β1 LoxP1 animals were populated by cells retaining expression of β1-integrin and lacking Cre expression.
Tumours with staining in at least 50% of cancer cells, were judged as having high GalNAc-T3 expression (retaining expression of GalNAc-T3).
Sordat et al (2000) reported that budding cells in colorectal carcinomas underexpress the laminin-5 α3-subunit, while retaining expression of the β3- and γ2-subunits.
A prerequisite for a duplication to spread through and persist in a given population is retaining expression of both gene copies.
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Tumor #200, from an Ink4a mouse, retained expression of Arf but did not express p53 protein.
Western blot analysis showed that transformed IAR-6-1 epithelial cells retained expression of epithelial E-cadherin and did not express mesenchymal N-cadherin (Figure S1).
The resultant cell lines express an HCEC-specific transcriptional fingerprint, and retain expression of the corneal endothelial temperature-sensitive potassium channel, suggesting that significant dedifferentiation does not occur as a result of these modes of immortalization.
However, apparently contradicting its role as a classical tumour-suppressor protein, colorectal cancer cells retain expression of the retinoblastoma tumour-suppressor protein (Rb); they express high levels of Rb compared with adjacent normal tissue, and loss or mutations of the RB gene are rare.
We hypothesised that the retained expression of AQP1 in this tumour may offer treatment potential to AQP1-expressing tumours.
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