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32 In animal models of diabetes, INT131 caused less weight gain compared with pioglitazone or rosiglitazone, while retaining efficacy to reduce plasma glucose.
Others have used glycosylated lipoproteins or arabinogalactan as liver-accumulating carriers for targeted delivery of antiviral drugs to the liver, potentially retaining efficacy with a reduced dose [ 8].
Current WHO guidelines recommend a weekly dose of 0.75 mg/kg for 8 weeks which mitigates primaquine-induced haemolysis [ 6] whilst retaining efficacy [ 7].
The data indicate there may be potential in using mixes of antioxidants in the treatment of RA alongside drug treatment so that drug dosage may be reduced while hopefully retaining efficacy.
Novel analogues of CsA and FK506 named ISATX247 and L732531 respectively, exhibit significantly less toxicity while retaining efficacy, and may have a place in future cancer therapy directed at NFAT inhibition (Dumont, 2000; Aspeslet et al, 2001; Stalder et al, 2003).
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After 10 years as the first-line antimalarial drug, has sulfadoxine-pyrimethamine retained efficacy in Malawi?
These results extend the existing deimmunization literature, in which reduced immunogenicity and retained efficacy are assessed independently of each other.
A method to prepare a self-healing, antimicrobial polymer coating that retains efficacy against Escherichia coli O157 H7 in the presence of organic matter is reported.
In spite of its short plasma half-life of the parent molecule, SU101 can be administered intermittently in animal tumor models and retain efficacy.
Equally, the ever expanding quantity of data which biobanks will collect and generate about a data subject means it is difficult to state that any anonymisation or pseudonymisation process will retain efficacy over time.
The lead "switch-control" inhibitor, DCC-2036, potently inhibits both unphosphorylated and phosphorylated ABL1 by inducing a type II inactive conformation, and retains efficacy against the majority of clinically relevant CML-resistance mutants, including T315I.
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