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"Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state". Curr Biol 22, no.
Putative epithelial stem cells were identified in the hair follicle bulge as quiescent "label retaining cells".
CD34 expression colocalized with both slowly cycling (label retaining) cells and keratin 15 expression.
Further, the duration of time that the analog is maintained can be used to extrapolate the cycling rate of the label retaining cells (LRCs).
We therefore examined the state of histone modifications in label retaining cells (LRC) in whole mounts of mouse tail epidermis (Fig. 2A F) [2A F
When plasmid selection (-URA) was maintained throughout the experiment so that only plasmid retaining cells would survive, a rapid time dependent decrease in survival was observed.
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The increase in the relative abundance of label-retaining cells was not due to increase in the number of label-retaining cells but was due to decrease in cells without label.
Since all label-retaining cells are not expected to be synchronous and therefore all label-retaining cells may not undergo cell division during the pulse with BrdU, only a small fraction of EdU-retaining cells incorporated BrdU but the number of cells with colocalization increased with increasing number of days in BrdU pulse.
Chan, R. W. & Gargett, C. E. Identification of label-retaining cells in mouse endometrium.
Buczacki, S. J. et al. Intestinal label-retaining cells are secretory precursors expressing Lgr5.
Li, N., Nakauka-Ddamba, A., Tobias, J., Jensen, S. T. & Lengner, C. J. Mouse label-retaining cells are molecularly and functionally distinct from reserve intestinal stem cells.
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