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By contrast, blockage of cell growth/proliferation by inhibiting EGFR pathway or by inactivating dMyc only resulted in a gradual decline in the ISC number; and Ras or dMyc mutant clones retained the stem cell marker for a long period of time (2 3 weeks) even though they failed to divide (Xu et al., 2011; Ren et al., 2013).
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GPS cells also express E-cadherin and b-Catenin in a polarized manner (coronal vs. axial) surrounded by Vimentin+ cells, suggesting a putative relation with the known function of the Wnt/b-Catenin pathway together with E-cadherin to retain the stem cells within the niche confines [60].
This design feature decreases implant inventory and simplifies subsequent revision by offering the option of retaining the stem and performing a head exchange.
Thus, the "item-improved" instruments retain the stem of the original items, but have "improved" the tense to "present" and the response categories to "five" (together with minor improvements in clarity and phrasing).
The research on stem cell biology has predominantly focused on the use of soluble chemical cues to retain the stem cell phenotype and direct lineage commitment, but now there is mounting evidence that substrate stiffness and nanotopography could potentially be used as versatile tools for the non-invasive manipulation of stem cell proliferation and differentiation.
The cherry with stem attached can be placed in the mouth and eaten, retaining the stem and stone for the trick.
Maintaining a suitable culture environment is essential for retaining the stem-like characteristics of ASCs.
In Drosophila male germline stem cells, the mother centrosome is retained by the stem cells, whereas the daughter centrosome is segregated into the differentiating gonial cell following division [ 42].
Elegant experimental evidence exists that a stem cell chromatin strand is retained in the stem cell progeny of asymmetric divisions (Cairns, 1975; Merok et al, 2002; Potten et al, 2002).
The two copies of the A repeat isolated from both species here retain the same stem and loop sizes shown to be important for Xist silencing in Mus [68], suggesting continued functional selection.
Daughter cells that inherit the apical membrane retain the proliferative stem cell properties of the parent cell.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com