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Single-copy orthologous genes have likely retained the same function even over long evolutionary timescales [ 6].
However, genes shown to be descendants of the same gene (orthologous genes) have, in general retained the same function over the course of evolution [ 10].
In modern eudicot species, these three homologous copies may have or may not have retained the same function as the ancestral gene.
Grimme et al. (2004) demonstrated that the C. albicans mannosyltransferase Smp3, involved in the synthesis of the GPI-anchor glycan, retained the same function as its S. cerevisiae ortholog.
Likewise, Zhang et al. found that an albumin gene, encoding a seed storage and insect toxin protein, was transferred from legumes to the root parasitic plant Orobanche aegyptiaca and shoot parasitic plant Cuscuta pentagona and probably retained the same function after HGT [ 35].
However, since the purpose of this analysis was to identify genes that most likely retained the same function rather than orthology sensu stricto, it is possible that in some cases a paralog (in-paralog) was selected as the most promising ortholog.
Similar(54)
When orthology is unambiguous, proteins in the different species generally retain the same function, essentially when the function is critical to survival [34].
In the bloodfeeding diptera Lutzomyia longipalpis, variants of the maxadilan protein retain the same function and biochemical properties [47] but have undergone diversifying selection (Lanzaro, personal communication).
Paralogs usually display different functions, whereas orthologs may retain the same function [ 71].
Paralogs usually display different functions, while orthologs may retain the same function [ 1].
Orthologs generally retain the same function over the course of evolution.
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