This procedure allows getting a more hydrophilic scaffold but also retaining the protective polymer inside the microcarriers during their degradation.
Any improved vaccine regime against TB should include BCG, administered in infancy, in order to retain the protective effects against severe childhood disease [5], [6], [7].
These protection and biochemical data indicate that the loop regions proximal to short helices (α8 and α9) are critical for the recognition and protection by Mab166 and that the epitope region appears to be structurally flexible and retains the protective role irrespective of the 19-residue insertions.
While several of these studies evaluated GMTs after a short period following vaccination, there is evidence that higher GMTs established initially correspond to higher proportions of participants retaining the protective bactericidal antibody threshold during long-term follow-up [ 42].
To determine whether transplanted epithelium from E+P-treated donors may retain the protective effects of the hormone stimulation after transplantation into the cleared fat pad of nulliparous hosts, we compared tumor incidence and latency between glands bearing transplants of Trp53+/- mammary epithelium from nulliparous versus E+P-treated donor mice.
Meta-analysis results with the other three studies on the Pakistani population retained the significance of protective effect of DR 11 as well as DQ02.
Using an erythrocyte-protection assay, we demonstrated that most of the translocation-competent mutants retain the conformational protective epitope.
The AAFA system is able to maintain a sufficient high pH to retain the passive protective layer on the surface of any reinforcing steel present.
Production of OspC with 5-AA deletion fully restored OspC-deficient B. burgdorferi with ID50 values similar to the control, indicating that the truncated molecule retains the full protective function of OspC.
Although the 5-AA deletion retains the full protective function of OspC, several other deletions, including that of the N-terminal 10-AA, α-helix 4 (8 AA), and β-sheet 1 (5 AA) and 2 (5 AA), completely destroys its protective function (Seemanapalli and Liang, unpublished data).
