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Although both Ski- and SnoN-DHD are protein-interacting domains, their DHD fold has retained the interaction site from their DNA-interacting winged-helix relatives.
If the mapped pairs still included inparalogs in P. infestans, we disentangled these specific cases by applying four different functional criteria to define which of the P. infestans proteins most likely retained the interaction.
However, under the same conditions, a mutant of Dvl2 that is devoid of the N-terminal DIX domain involved in oligomerization (Schwarz-Romond, 2007) (Dvl2ΔDIX) retained the interaction with BPN.
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Correlations have been found among interacting residues as a result of selection pressure to retain the interaction during evolution.
A random-factor model without the interaction effect has higher AIC and BIC values, so we retain the interaction.
Age interaction terms (dichotomized by <60 vs ≥60 years) were tested in the fully adjusted models, retaining the interaction term if the interaction probability value was <0.05.
To obtain a model of constant population size that is comparable to the one described above, we retain the interaction matrices and adjust the host birth rate and parasite death rate to maintain the population size.
Evolutionary data were also used to detect couplings (co-evolution) where both amino acids change in tandem to retain the interaction (Marks et al., 2012; de Juan et al., 2013).
The final model for MOOD retained the two interaction effects of gender by MOOD and centre by MOOD.
These horizontally aligned, texturized surfaces were used to compare with the CNW surfaces, as they provided both a reduced graphene surface area (with only one plane available) and fewer topographical features for biological interactions while retaining the interactivity with the complex chemical system of the culture medium.
p-TAREF has been designed specifically to detect plant miRNA targets, applying the following basic steps: A) Conversion of target:miRNA pairing into single dimension encoded pattern for interactions, which retains the various interaction features combinations found in plant system.
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