Sentence examples for retained the binding from inspiring English sources
The results showed that the Ile529Ala and Asn560Ala mutants retained the binding activity to 8C11, but they can't bind to 8H3 with the presence of 8C11 (Fig. 2B), suggesting that the epitope of 8C11 was retained, but the epitope of 8H3 was damaged in mutants Ile529Ala and Asn560Ala.
Thus, biotinylated Ins(1,3,4,5 P4 retained the binding affinity and selectivity of original Grp1 PH domain, and realized the intracellular Ins(1,3,4,5 P4 despite a tethering at the 1-phosphate group of inositol.
We have also created functional single-chain miniantibodies from selected POMs, which retained the binding characteristics despite their low molecular mass.
Interestingly, mutant SU with substitution of Q396N retained the binding affinity to CXCR4, whereas, alteration of N398Q completely abrogated CXCR4 binding ability, although both residues were replaced by the same character of amino acid residue.
These findings are fully compatible with the functional analysis in which the A to C substitution, that diminished transcription also failed to bind TISU, while the first four nucleotides which were dispensable for TISU function, retained the binding activity.
After PEGylation, mPEG-rLDP still retained the binding capability to the enediyne AE and presented the physicochemical characteristics similar to that of native LDP.
Since the d1Δ mutant retained the bindings to Hrd1, Hrd3 and Der1, the results also suggest that the extreme N-terminal domain of Usa1 plays a different, but undefined essential function in ERAD-L ubiquitylation.
hu5A8 is a molecularly engineered human IgG4 antibody retaining the binding and functional properties of the murine version of 5A8 (mu5A8).
Engineered monovalent antibody/ligand pairs that retain the binding specificity of the antibody, but do not dissociate, are promising components of new delivery systems.
Single-chain variable fragment (scFv) antibodies retain the binding specificity of antibodies and, when genetically manipulated to create high-diversity libraries, allow in vitro selection against peptides.
The design of such protein binding molecules is often based on an antibody against the target protein, or involves the generation of smaller molecules that retain the binding characteristics of the antibody.
