Sentence examples for retained specificity from inspiring English sources

The mutant retained specificity for ATP; ADP and GTP bound to the mutant with dissociation constants 16 and 53 μM, respectively.

Conversion from an acidic to a basic residue at this site (E1544K) results in a sixfold enhancement of affinity via modification principally of the association rate, with enhanced salt-dependence, decreased entropic barrier and retained specificity.

This underscores that the reagents produced are correctly folded and retained specificity, which was the major goal in this study.

Nearly all charge mutants showed severely reduced binding, but retained specificity for H3KC36me3 nucleosomes (Additional file 1: Figure S5a).

Additionally, the Ad/GFPDiSTRES vector retained specificity in the two non-prostate cell line controls, HeLa and U251MG.

The design retained specificity and catalytic activity and crystallized with an rmsd of 0.8 Å with respect to the model (77).

A key question we sought to address was how one binding site could specifically recognize and transport such a large number of different ligands, while retaining specificity for peptides only two or three amino acids long.

This review will also focus on engineering of smaller versions of antibodies that retain specificity (single chain Fvs, Fabs, Fab2s, minibodies, domain deleted antibodies) and have increased penetrability of solid tumors.

To assess whether MRBL-borne modifiEGFEGF receptors retain specificity for EGF, binding of radiolabeled [125I]EGF to reconstituted receptors was assessed with and without pre-incubation of the MRBLs with an excess of unlabeled EGF.

To identify the components underlying the EGF sensitivity of MRBLs, it was noted that modified EGF receptors retain specificity for EGF; modified EGF receptors form dimers in the presence of EGF; and MRBLs bearing these receptors exhibit sensitivity to EGF in solution.

Histology, H&E and IHC stains retain specificity for CMV disease.