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While the new title compounds indeed inhibited ALK and several ALK mutants in submicromolar concentrations, they retained poor water solubility.
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Although later converted to standard gauge and electrified, the line retains poor capacity and many curves.
She said she felt as if she were "a lawyer who has been retained by poor people in developing nations".
They retained the poor response of Socs3 to LIF without Tx.
In the final Cox model for multivariate analysis (Table 3 > -wrap-foot>), presence of ascitis (P=0.008) and HER-2 overexpression (P=0.001) both retained a poor prognostic impact on progression-free survival.
In the multivariate analysis, tumoral CD105 expression retained the poor prognostic significance for OS (HR=3.76, 95% CI=1.63 8.66; P=0.002) and was associated with shorter DFS with marginal statistical significance (HR=2.82, 95% CI=0.99 8.05; P=0.053).
Ovarian cancer retains a poor prognosis among the female gynaecological malignancies.
The incidence of digestive cancers is still increasing, mainly due to colorectal cancer trends (Parkin et al, 2002), and retains a poor prognosis, as reported by the European Cancer Registries EUROCAREE) study (Berrino et al, 2003).
Novel drugs including immunomodulatory agents and proteasome inhibitors have improved outcomes in plasma cell dyscrasias, but high-risk multiple myeloma (HRMM) retains a poor prognosis and remains a therapeutic challenge.
Furthermore, even if it were possible to produce a cysteine mutant that retained activity, the poor efficiency of polymer conjugation to the thiol group made it impossible to obtain the desired product.
The tolyl group of 2 was not retained due to poor solubility.
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