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Only Δ26 FMO variants retained normal activity, increased the yield of cytosolic rF2 and decreased protein aggregation.
Monocytes and peritoneal macrophages exhibited reduced anticryptococcal activity 14 days after infection with HIVBal but retained normal activity when infected with HIVIIIB.
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Thus, although the amount of enzyme decreases significantly in the tissues, the enzyme that retains normal activity can contribute significantly to the amount of residual activity in these mice.
Thus, siRNAs from FOP patients have been utilized to retain normal activity of BMP [ 37, 38].
Given the large number of single amino acid changes along the length of NEMO that are associated with human disease, we find it surprising that a NEMO protein with eight scattered amino acid changes (as in L107C)) retains normal activity.
We previously reported that chronically hypoxic flies retain normal activities but age at a faster rate than normoxic flies.
Alveolar macrophages retained normal anticryptococcal activity whether infected with HIVBal or HIVIIIB.
It was confirmed that all active-site labeled factors lacked protease activity, but retained normal binding properties [16], [17].
Neurons outside the zone of VAMP depletion retained normal inhibitory and excitatory synaptic activity.
Thus, negatively isolated neutrophils retain normal functional activity in vivo.
The mutant protein is stable in vivo and retains normal kinase activity in vitro (Supplementary Figure S8).
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