Sentence examples for retained moderate from inspiring English sources

As a result, we discovered compound 1a, which retained moderate SCD1 binding affinity.

Furthermore, 1C7-LSD1K661A cells retained moderate levels (∼30%) of transcriptional activity at the HAC centromere even after 3 days of targeting.

NCI-Meso18, which was derived from an epithelioid mesothelioma, retained moderate expression of calretinin and minimal expression of mesothelin and WT1.

V144M telomerase retained moderate telomerase activity and high processivity (48%and95%5% of wild-type telomerase, respectively) but POT1-TPP1 RAP stimulation was significantly decreased to 61% when compared to wild-type telomerase (Table 1, Figure 5 figure supplement 3).

We generated a R132E mutant hTERT, which retained moderate activity (73%) but was defective in RAP stimulation by POT1-TPP1 (24% of wild-type hTERT, Figure 1E H; Figure 1 figure supplement 2).

This suggested that these central mismatches abrogated RISC-mediated cleavage of the mRNA, but that translational suppression, causing the retained moderate reduction in VEGF-A protein levels, was less dependent upon complementarity at these central positions.

In particular, some examples, such as compounds 6 and 10, shows decreased calculated lipophilicity, when compared to PCP, while retaining moderate activity.

Based on the planar X-ray crystal structure of WAY-362450 1 in the ligand binding domain and molecular modeling studies, non-planar reduced compounds were designed which led to agonists that exhibit high aqueous solubility and retain moderate in vitro potency.

Given that there were more than twice as many voters in the latter category (11% of all voters) than the former (5% of all voters) in 2008, it stands to reason that veering toward the middle and trying to retain moderate Democratic partisans may be the option with the higher pay-off.

Telomerase is not expressed in most normal somatic cells but retains moderate activity in proliferative stem cells and to a higher extent in male germ line cells.

(Saxifragaceae) [47], have been found to retain moderate to high genetic diversity or at least high heterozygosity despite historic grazing by goats.