This is seen in the onset of cNkx2.8, which appears at heart primordia and retains its expression until primary heart tube formation.
Poxn also retains its expression in all postmitotic GRNs and thus serves as an excellent marker for these neurons.
The factor Z represents a terminal endocrine fate marker downstream of Ngn3 such as Isl1[ 35] 35] that, once induced, retains its expression by positive auto-activation.
Bcl-xL is encoded by the Bcl-x gene and, differently from Bcl-2, retains its expression in adult neurons at a relatively high level, predominantly in Purkinje cells in the cerebellum, in cerebral cortical neurons and in hippocampal neurons.
Gata3 instead retains its expression at the periventricular and intermediate raphe pronuclei of the rostral cluster (the continuous positive periventricular stratum now stops at the r3/r4 limit; Fig. 8l); the ventrolateral superficial column (prospective SuL) does not show significant signal.
Age, stage and Bcl-2 expression were significantly associated with survival and Bcl-2 expression retained its prognostic value such that NSCLC patients with high Bcl-2 expression had a 47% reduction in risk (HR = 0.53, 95% CI 0.37-0.75, p = 0.0003; Table 2).
In our current study we observed that a high VEGF expression was significantly associated with poor prognosis and, most important, that in multivariate analysis VEGF expression retained its prognostic significance on OS.
Perinecrotic HIF-1α expression retained its prognostic significance in the subgroup of low stage, while significance was lost in stage III/IV patients, indicating that HIF-1α expression seems to be especially important in low stage patients.
More importantly, BAX mRNA expression retained its independent prognostic significance in NPC (HR = 0.36, 95% CI = 0.16 0.84, P = 0.018) even when the multivariate Cox regression model was adjusted for patients' gender, age, tumor histology, and TNM stage.
