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Her spine was crushed, and while she retained function in her arms, she has none in her lower limbs.
For MscS, we have previously shown that Trp can be substituted into the pore for Leu at positions 105 and 109 and the resulting channels assembled in the membrane and retained function in physiological assays, albeit at a lowered level relative to that of the wild type.
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As with the Class II proteins, these may have retained functions in SCW regulation or, as with Class III Arabidopsis proteins, developed new functions.
The control measures centre about developing resilience and emergency response and preparedness, and design of organizational and operational structure to retain function in the face of adversity and catastrophe.
These multiple structural requirements limit the opportunities for creation of mutations that lack diphthamide while retaining function in protein synthesis.
First, in armXM19 (M/Z) mutants, the truncated ArmXM19 protein does not activate the Wg signal in the nucleus, but does retain function in the adherens junction[31].
Several mammalian splicing components have been shown to exit the nucleus and retain function in the dendroplasm, perhaps to provide localized mature mRNAs for localized translation of specific transcripts (Glanzer et al. 2005; Bell et al. 2008).
The glucose biosensor retained its function in complex solutions that contained realistic concentrations of protein and potential interfering agents found in blood serum.
These same OSER structures could be observed when b5-GFP fusion proteins were over expressed, as long as they retained dimerization function in either the b5 or GFP protein domains.
All these end points indicate some retained ATM function in cells from patient A-T213.
This suggests that Mig3p has retained some function in the lab strain despite the significant Mig3p-signaling defect.
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CEO of Professional Science Editing for Scientists @ prosciediting.com