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The super stability with retained function results from the "hydrophobic effect" of supramolecular self-assembly of peptides and drugs.
Noyes et al. demonstrated that a successful meniscal repair with apparent retained function was achieved and maintained during 10 20 years postoperatively in 62% patients using an inside-out multiple vertical divergent suture technique (Noyes and Barber-Westin 2002).
Her spine was crushed, and while she retained function in her arms, she has none in her lower limbs.
We also recently demonstrated that non-specific "amine-directed" labeling of a cell death SPECT imaging agent, C2A (a domain of synaptotagmin I), led to abolition of binding to its target, phosphatidylserine, while the inclusion of a novel site specific C-terminal hexahistadine tag fully retained function [17].
All other retained homeologs appear to be under purifying selection for retained function.
Based on our knowledge of Neurospora telomere binding proteins, it is likely that Tbf1 end-capping in S. cerevisiae [ 25] is a remnant of an evolutionarily retained function.
Similar(48)
However, some variants retained functioning similar to the wild type.
In all cases, the obtained conjugates retained functions of individual modules.
As with the Class II proteins, these may have retained functions in SCW regulation or, as with Class III Arabidopsis proteins, developed new functions.
"The premise of orthopedics is to restore alignment so you can retain function," says Lieberman.
And in both the mind-door and five-sense door processes, when the retaining function ceases, the mind reenters its inactive mode.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com