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The presence of a discernable signal in samples derived from higher eukaryotic species suggests that, despite the lack of an obvious cellular phenotype in yeast to date, this mark is likely to be biologically important since it was retained during evolution.
When the principle and alternative protein isoforms each confer a selective advantage, both are likely to be retained during evolution.
Probably this complex has been retained during evolution for tryptophan synthesis, as it enables substrate channelling and allosteric regulation.
This might be an explanation for why the copies of the fish-specific duplication in PK1 were retained during evolution.
Thus, it is feasible to speculate that the conserved N-terminal motifs of the different Pti1 subfamilies were retained during evolution because of specific relevant biological functions.
Of relevance here is the demonstration that in yeast selection against duplicated gene copies was enhanced, while gene copies retained during evolution fulfilled functions different from ancestral [ 129].
Similar(43)
This suggests that these four conserved introns (I1, I2, I4 and I6) were retained during the evolution of different plant lineages from algae to angiosperms, but other introns were lost during the structural evolution of OPR paralogues in each plant lineage.
CTCF, and RNAPII proteins were continuously created and retained during the evolution after the Euarchonta and Glires split approximately 88 Ma.
Unlike DJ-1 proteins, Hsp31 proteins are widely distributed among phylogenetically distant fungal species, indicating that Hsp31 proteins were retained during fungal evolution.
Although prolonged low temperatures are not required for flowering induction in soybean, vernalization pathway genes have been retained during the evolution of this species.
Many of them might not have a direct role in the specific tumour or might be passengers, that is, cancer-neutral variants that are retained during the evolution of cancer (Futreal et al, 2004).
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