Sentence examples for retain wild type from inspiring English sources

Mutations within the p53 gene, leading to the loss of p53 activity, are found in about half of all human cancers, while many of the tumors that retain wild type p53 carry mutations in the pathways that allow full activation of p53.

The Arg101→Asp and Arg115→His double mutant, however, is the only variant thus far proven to retain wild type or better lytic activity in the absence of inhibitory biopolymers (Fig. 1).

The Dmp1+/- tumors often retain wild type allele of DMP1, thus DMP1 is haplo-insufficient for tumor suppression [ 37].

Interestingly, patients with tumours that show elevated PLK1 expression, but retain wild type TP53, have a relatively favourable outcome.

* Tumours where multiple mutations were present An additional issue is that the association between PLK1 expression and TP53 mutational status is not absolute; for example, some tumours show elevated PLK1 levels yet retain wild type TP53 (Table 1).

For those tumors that retain wild type p53 (p53 wt), maintenance of the tumor phenotype depends on its ability to hold p53 wt in an inactive form even long after the initial transformation events [ 1- 4].

These findings suggest that the combined use of ABL kinase inhibitor and DNA damaging drug in chemotherapy against tumors retaining wild type p53 should be carefully designed.

As expected, Sec24C morphants retained wild type appearance throughout the observation period, whereas Sec24D morphants showed the first defects shortly after the 48 hpf time mark.

When introduced into human cells, the viral DNA sequence of this construct, TowneBAC, produces infectious progeny and retains wild type growth characteristic in vitro.

In addition, the over-expression of MDM2 and/or MDMX is generally accepted to correlate with retained wild type P53 [ 27].

Furthermore, the retained wild type matrilin-3 was not present as high molecular weight aggregates in the Comp DelD469 chondrocytes (not shown).