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While many orthologous genes retain their functions between dipterans, large regions of gene sequence are often not conserved [ 18, 59].
This in addition to uncharacterized properties of certain neuronal cells may explain why spinal cord and brainstem where rabies virus was found heavily and early in the disease course, yet still retain their functions.
For the previously well-established tools of 'PTMsite-Map' (Supplementary Figure S2E), 'PTMsite-Table' and 'PTMsite-Cluster' (Supplementary Figure S2C), we retain their functions to display all information related to a protein PTM site such as data source, integrated annotation, predicted and calculated P-values, etc. either graphically or in tabular form.
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Introduction of antibodies which retain their function into cells using a simple and easy method would be very useful for study of the intracellular events in living cells.
Level II of factors PGE1, l-arginine, phycicacid sodium, and Bivalirudin could inhibit the activation of platelets and enable them to retain their function.
The 12 steps in front of City Hall retain their function as the place where mayors are sworn in, ceremonial speeches made, distinguished visitors receive the key to the city, heroes of the fire and police departments are awarded medals and baseball heroes, like the Mayor's Yankees, are honored.
Genes in the same pathway can retain their function in organisms separated by a billion years of evolutionary history.
The ability to cryopreserve lymphocytes in peripheral blood mononuclear cells (PBMC) to retain their function after thawing is critical to the analysis of cancer immunotherapy studies.
In other disorders, qualitative studies have shown that patients use medications to retain their function [28], e.g. the overall expectancy among patients with rheumatoid arthritis was that the medication would minimize the personal impact of the disorder [29], and asthma patients described using medications in order to be able to live normally [28].
These cysteine-modified receptors retain their function and lead to preferential pairing, thus interfering with heterologous chain pairing between introduced and endogenous receptors [51].
It is likely that certain residues in certain positions are required for the function of the protein and the de novo design may be focused on the set of sequences which are more stable than the native ones, but in the vicinity of the native so that they retain their function.
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Justyna Jupowicz-Kozak
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