Sentence examples for retain the binding from inspiring English sources
Engineered monovalent antibody/ligand pairs that retain the binding specificity of the antibody, but do not dissociate, are promising components of new delivery systems.
Single-chain variable fragment (scFv) antibodies retain the binding specificity of antibodies and, when genetically manipulated to create high-diversity libraries, allow in vitro selection against peptides.
The design of such protein binding molecules is often based on an antibody against the target protein, or involves the generation of smaller molecules that retain the binding characteristics of the antibody.
These molecules retain the binding affinity for Cyp, but do not inhibit calcineurin, which is the molecular target underlying the immunosuppressive activity of CsA [21].
Other novel functions such as agglutination capabilities at physiological temperatures can be imparted on Tsps through mutations that eliminate the enzymatic activity, but retain the binding activity [25], [33].
Therefore, in a number of in vitro functional assays, recombinant VCN was found to retain the binding properties of native CN, while showing an improved binding affinity compared to native CN for one important receptor in angiogenesis, integrin α5β1.
The results showed that the Ile529Ala and Asn560Ala mutants retained the binding activity to 8C11, but they can't bind to 8H3 with the presence of 8C11 (Fig. 2B), suggesting that the epitope of 8C11 was retained, but the epitope of 8H3 was damaged in mutants Ile529Ala and Asn560Ala.
hu5A8 is a molecularly engineered human IgG4 antibody retaining the binding and functional properties of the murine version of 5A8 (mu5A8).
Thus, biotinylated Ins(1,3,4,5 P4 retained the binding affinity and selectivity of original Grp1 PH domain, and realized the intracellular Ins(1,3,4,5 P4 despite a tethering at the 1-phosphate group of inositol.
Here we report the cloning of the genes encoding the variable regions of CG10 heavy and light chains and demonstrate that when attached to human IgG1 Fc, the single chain Fv of CG10 retains the binding properties of the original mouse antibody.
This structure still retains the binding properties of classical antibody.
