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Presence of cells that remain undivided for several cell cycles suggests that stem cells in hydra share at least one characteristic of cell cycle regulation with mammalian stem cells, namely the ability to retain stem cells in slow-cycling state.
That study demonstrated that label-retaining mammary epithelial cells are stem cells and that their progeny (transitional cells) are arranged as transitional units, and also demonstrated that both cells express Zonula Occludens-1 and α-catenin proteins, data suggesting that transitional units retain stem cells.
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The cancer stem cell hypothesis predicts that the chemotherapy-resistant ALDHhigh cells should retain stem cell activity.
The 'central cells' were more likely to retain stem cell capacity compared with the 'border cells'.
At least some of their progeny has to retain stem cell function in order to maintain the stem cell pool.
All these aspects are dynamically orchestrated in vivo in order to retain stem cell identity, guide cell fate determination and maintain stem cell pool.
In rodents, it remains controversial whether stem cell capacity resides exclusively in the As pool, or a fraction thereof, or whether Apair cells also retain stem cell activity.
TERT is expressed in normal hematopoietic stem cells; thus, these findings are consistent with the notion that both CD34+ and CD34− B-ALL blasts retain stem cell function.
If, as speculated above, these CSCs originate from ductal progenitors, they probably retain stem cell properties of their ancestors throughout the differentiation and oncogenic transformation process.
Recent evidence has provided support for the 'cancer stem cell hypothesis', which holds that cancers originate in tissue, stem, or progenitor cells; hence, carcinogenesis is driven by a small group of cells that retain stem cell properties [ 2].
Asymmetric divisions giving rise to more differentiated progeny can be observed at almost every stage; satellite cell lineage progression thus allowing for a small population of satellite cells to retain stem cell characteristics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com