MSH6-deficient cells are unable to repair single base mismatches, whereas they retain proficiency to repair two, three and four base loops (Drummond et al, 1995; Risinger et al, 1996; Umar et al, 1997), thus, causing only mononucleotide repeat instability in tumours (Wagner et al, 2001; Plaschke et al, 2004).
Studies have shown that students from low-income families tend to lose on average two months of reading proficiency through the summer months, while those from middle-class families retain their proficiency levels or improve during summer vacation, Gallagher noted.
He retained reasonable proficiency in Italian for the rest of his life, albeit reportedly with an "atrocious" accent.
Immune profiling of our series of patients with HER2-overexpressing BC demonstrated a retained immune proficiency at diagnosis [ 13].
In the absence of anthracyclines, trastuzumab and paclitaxel induced a high rate of pCR, exploiting the synergy between the immunomodulating properties of these drugs and the retained immunological proficiency of patients with HER2-overexpressing BC.
The likely retained immune proficiency of HER2+ patients is supported by an apparently unchanged cytokine profile, as sharpened by the comparison with serum cytokine levels of healthy women, which displays no significant differences.
The setting of HER2-overexpressing BC is particularly suited to carry out this analysis, considering our previous results indicating that these patients, at diagnosis, retain an unaltered immune proficiency that can be exploited by NC drugs such as trastuzumab or taxanes [ 13].
Also, it was decided that all of the speaking tasks would be retained in the proficiency test.
We also retain individuals aged 60 65 when considering proficiency in fundamental skills and skill use, but exclude them when examining the effects of VET on labour market outcomes, because of the selection problems associated to retirement.
Middle proficiency group The general tendency is retained in the middle proficiency group.
Such particles are devoid of Vpr and retain their transgene-transferring capability and integration proficiency, with the latter property depending on the vector-contained IN-protein composition [ 8, 10].
