They retained normal levels of non-GPT neurons, which transiently increased their density due to the paucity of viable GPT neurons.
Furthermore, we investigated DNA hypermethylation events specific for precursor (PXA-4) and anaplastic (PXA-5) PXA cases that retained normal levels in the rest of the samples, including GBM, and therefore represent specific DNA hypermethylation events of this tumor entity.
In parallel, IN-V5 carrying a D116G mutation at the IN catalytic sites was also tested, since HIV-1 with a D116G variant of IN is defective for proviral integration but retains normal level of cDNA synthesis (reverse transcription) activity [11], [29], [30].
Despite the lack of T and B cells, they retain normal or even higher levels of other bone marrow-derived cells, such as macrophages and natural killers (NK cells) [32].
Studies were performed with floxed GC-A mice (controls, which retain normal GC-A expression levels) and EC GC-A KO littermates (floxed GC-A mice harbouring the Tie2 -Cre transgene, which drives the expression of Cre-recombinase in endothelia) in a mixed genetic background (C57BL/6J/129SV).
Our previous work with the Smn 2B/− mice revealed an intriguing phenotype the mice were hyperglucagonemic but retained normal insulin levels (28).
SCID/uPA mice with high levels of human liver chimerism have been shown to retain normal pharmacological responses and therefore are potentially useful for human drug metabolism studies[11].
Apparently atypical tRNAs retain normal function, thus exemplifying the concept of a minimal tRNA [ 2, 6], a structure approaching the minimal level of simplicity necessary for a functional translational system.
Thus, negatively isolated neutrophils retain normal functional activity in vivo.
Furthermore, Smad4 expression was lost in 10 of 41 primary squamous cervical carcinomas and reduced in 26 cases as shown by immunohistochemistry, whereas all cervical intraepithelial neoplasias (CIN) retained normal Smad4 expression levels.
