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However, when tested in the multivariate analysis, it did not retain its prognostic value (p = 0.546).
However, when Mcm2 positivity was tested in the multivariate analysis in combination with LDH, IPI, and Ann Arbor stage it did not retain its prognostic value (p = 0.546).
The ultimate goal was to examine whether Sox11 expression may vary according to the phenotypic subgroup of astrocytic tumours and may retain its prognostic utility in a multivariate analysis, including conventional prognosticators and the phenotypic subgroups.
Indeed, the identification of LCA MB will likely retain its prognostic significance, even when molecular sub-grouping will more frequently be used in clinics; in this context, JAG2 may represent an additional potential marker for high MYC/LCA MB tumors.
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Moreover, the NPI has not been evaluated in a neoadjuvant setting and, as for the SBR grade, we could wonder if it retains its prognostic value after primary chemotherapy.
Therefore, our findings suggest that our gene signature retains its prognostic relevance, even after the "classical" pathological prognostic features have been taken into account.
Phospho-MET retained its prognostic value in a multivariate analysis.
However, comorbidity retained its prognostic value after adjustment for age.
Furthermore, HER4 retained its prognostic power for DFS in the multivariate analysis.
Moreover, HER2 retained its prognostic value for OS in the multivariate analysis.
MeHPLAase activity status retained its prognostic significance also in the lymph node-negative subgroup of patients.
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