Our results show that ER is necessary for the proliferation of resistant cells signifying the retained importance of the ER in driving growth of these cells.
In the 20th century, as coal-mining employment declined, it grew as the service centre for the surrounding communities and acquired many new industries while retaining importance as an agricultural market.
The older biblical conception of Hades-Sheol as the gathering place of the dead retained its importance for the Christian tradition, however, as Christians reflected on the redemptive significance of Holy Saturday, the day between Christ's Crucifixion and his Resurrection.
Multivariate analysis of the training cohort indicated that IFN- α2 (P⩽0.001; HR, 7.486), GRO (P=0.016; HR, 2.426), and tumour multiplicity (P=0.019; HR, 2.117) retained their importance for predicting DFS.
Given the crucial role of PPARγ in adipocyte differentiation, it is tempting to suggest that the reason that these particular sites are retained is their importance for the overall regulatory regime, since they likely regulate a key transcription factor.
retain the importance of 'aloha.' " The dilemma for many Hawaiians, though, is that their "aloha" spirit has made them vulnerable to exploitation.
Possessory customs tend to be formalized into law, and yet for reasons of information cost, basic notions of possession retain their importance in many, especially informal, contexts.
Special beef breeds, for which Britain is famous, are raised throughout the country, but long-established specialist areas retain their importance.
Its sobriquet "the City of Light" ("la Ville Lumière"), earned during the Enlightenment, remains appropriate, for Paris has retained its importance as a centre for education and intellectual pursuits.
The topic chosen this year retains global importance and is one that allows for in-depth examination.
