Sentence examples for retain high affinity from inspiring English sources
We also introduced two mutants (cdk4G15A and cdk4R55A) that are defective in binding to cyclin D1, but still retain high affinity for the p16.
Further, the two double mutants of bH1-44 that retain high affinity for either HER2 LC-I29A/Y32A LC-I29A/Y32AC-R50A/R58A) exhibit the same prorile of faVEGFble HC-R50A/R58A HC-R50A/R58Aributions as bH1-44 (Figurexhibit
Recombinant fragments have been produced that retain high affinity for target antigens, and display a combination of high targeting specificity with concomitant clearance from normal tissues and the circulation in animal models.
Selected scFvs were converted to the Fab format, and the purified Fab proteins retained high affinity for antigen.
They retained high affinity for IL-2Rβ, inhibiting binding of endogenous IL-2, but their interaction with γc was weakened, attenuating IL-2Rβ-γc heterodimerization.
Most of the derivatives are based on the peptide sequence of truncated bombesin, bombesin (7-14) (BN(7-14): Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2), that retains high affinity for the GRP-R [8].
We show that the conjugated transferrin retained high affinity for its receptor and that the conjugate was specifically transported across an epithelial barrier, co-localizing with MHC Class II+ cells in the sub-mucosal stroma.
The second experimental approach was designed to verify whether or not the [NiFe]-hydrogenase of strain PCB7 retains high affinity H2 oxidation activity in soil, under the abiontic state.
These results indicate that the purified Unc45bFlag retains high affinity and selectivity for Hsp90 in this complex cytosolic fraction.
Herein, we report the placement of a pair of residues in the hCE1 active site that significantly increases the rate of nerve agent hydrolysis relative to native hCE1, while still retaining high affinity and selective functional substrate activity towards these compounds.
An important precondition for successful imaging was retained high affinity of the targeting agent.
