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We studied Fabs of IgG rather than F ab' 2 molecules since Fabs lack ability to both cross-link antigens and fix complement, whereas F ab' 2 molecules retain ability to cross-link antigens, though they have lost ability to fix complement.
Certain mutant pVHLs retain ability to regulate HIFs but lose their function by instability.
By contrast, Trail−/− mice retain ability to mount antigen-specific CD8 T cell responses to secondary heterologous bacterial infection after sepsis induction by CLP model (Gurung et al, 2011).
The mutant receptors are partially impaired in signal transduction activity, but they retain ability to undergo α-factor induced conformational changes and ability to undergo ligand-induced endocytosis (Büküşoğlu and Jenness, 1996; Schandel and Jenness, 1994; Weiner et al., 1993).
However, competitive inhibition by OH– binding as a sixth ligand does not suffice to explain the lower activity of Fe(Mn SOD because higher affinity for anions should also extend to O2–, which would therefore retain ability to compete with OH– for binding to the Fe3+(Mn SOD site just as it does for the Fe3+SOD site.
In E. amylovora, foxR mutants retain ability to synthesize desferrioxamine E, but lose their ability to utilize this as an iron substrate, are impaired in growth under iron-limited conditions such as found on flower surfaces, have reduced virulence, and are less resistant to plant defence responses [ 67, 68].
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This view is too stringent because it seems that we can retain abilities even at times when we are not actually exercising those abilities.
The concepts of sand retaining ability, anti-plugging ability, and flow capacity are put forward to describe screen comprehensive performance.
Patients with RB1 mutations that affect E2F binding, with retained ability to induce differentiation of tumor cells, had low penetrance of retinoblastoma [66].
Given these observations, and the retained ability of the Schu S4 ΔpurMCD mutant to induce tissue damage in the lungs following i.n.n
The other retained ability to form a thioester linkage with Sumo at Cys177, but harbored Ala mutations in the Ubc9-binding ufd residues Asp488 and Asp490.
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