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Figure 3 illustrates a powerful resuscitation effect of AspR in a cat.
Too low (40 mmHg) or too high (80 mmHg) target resuscitation pressure worsens the resuscitation effect [ 5, 7- 9].
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Interestingly, there were significant differences in the resuscitation effects among the three study groups.
Their resuscitation effects have significant age difference but had no sex difference.
A further experimental study demonstrated enhanced resuscitation effects with a combination of hypertonic saline and dextran [ 86].
This explanation has been substantiated by specific canine experiments conducted by Niemann and coworkers [ 6] that subsequently tested the resuscitation effects of high-dose adrenaline administered before and after countershocks.
To elucidate this issue, using uncontrolled hemorrhagic-shock rats of different ages and sexes (6 weeks, 14 weeks and 1.5 years representing pre-adult, adult and older rats, respectively), the resuscitation effects of different target pressures (40, 50, 60, 70 and 80 mmHg) on uncontrolled hemorrhagic shock during active hemorrhage and the age and sex differences were observed.
To elucidate this issue, using uncontrolled hemorrhagic-shock rats of different ages (6 weeks, 14 weeks and 1.5 years, representing immature, mature and older, respectively), the resuscitation effects of different target pressures (40, 50, 60, 70 and 80 mmHg) on uncontrolled hemorrhagic shock during active hemorrhage were observed.
Prior to steroid treatment, serum calcium levels (adjusted for albumin) were 3.27 mmol/L and fell to 2.61 2.71 mmol/L following fluid resuscitation (±prednisolone effect).
This study provides early evidence that efforts to translate this first demonstration of an estrogenic acute post-resuscitation renoprotective effect may best be focused on rapid effects which in the aged may be mediated by cognate estrogen receptors.
These include the choice of fluid used for resuscitation, the effects of hypoproteinaemia or the presence of other metabolites [ 19- 21], in addition to various 'physical chemical' approaches, including the calculation of the strong anion difference [ 22].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com