Fig. 5 COMSOL simulation results of device functionality.
Although the contribution of each domain such as the PUB domain or the mannose-binding domain remains unknown, the fact that the point mutation to the "catalytic" Cys resulted in loss of functionality suggests that some enzymatic function of this protein may be required for its proper function.
The rise in launch and use of small satellites in the past decade, a result of improved functionality through technology miniaturisation and alternative design philosophies, has spawned interest in the development of distributed systems or constellations of small satellites.
An EPSR2-specific intervention was any intentional modification of terminology between the prescriber's instructions on an EPSR2 prescription and that printed on the dispensed item's label, which was required specifically as a result of EPSR2 functionality, in order to reasonably fulfil the prescription as intended.
A general perspective on the development of the platform and its LU is presented, including the results of usability and functionality evaluations, which indicate that the platform and the LU comply with different functionality and usability criteria which are fundamental for their introduction into formal university courses.
However, such software development may not be successful, may result in loss of functionality or customers even if successful, and will in any event be expensive.
eBay is developing the new software in the event they lose the right to continue to license that technology, but warns that "such software development may not be successful, may result in loss of functionality or customers even if successful, and will in any event be expensive".
Five non-synonymous mutations have also been identified in familiar IGHD, at least one of which has been shown to result in loss of functionality of the GHRH receptor [12] [15].
This alternative initiation codon has been overlooked, or possibly avoided since it is out-of-frame with the cic traditionally used in matK translation, resulting in inconsistencies of functionality designation.
Most of the XLSA-associated mutations in ALAS2 are missense substitutions resulting in loss of functionality [ 20, 67, 69, 77, 78], whereas mutations in the ALAS2 regulatory region, such as the promoter [ 79] and intron 1 [ 8, 9, 80], lead to decreased ALAS2 expression.
