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Under the results domain, only 36% (22/61) and 7% (4/61) of tools included RE and QAA, respectively (table 1).
From the DCE results, domain 3 – tools/programs to provide staff with training in using research evidence – yielded the largest importance value.
In order to measure the precision and recall of the automated results, domain experts manually identified 76 tools that could answer, individually or as part of a computational pipeline, the specific clinical question.
In fact, based on our results domain shuffling was less in vertebrates compared to arthropods and nematodes, with G. gallus having the lowest domain shuffling index (as shown in [ 22]) among vertebrates (1.32 vs. 1.97 for M. musculus and 2.18 for H. sapiens).
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In a subsequent development phase, the resulting domain models can be used to guide the design decisions in the construction of different implementation artifacts addressing different computational concerns.
The resulting domain sequences of human STIM-1 and -2 were submitted to the SWISS-Model server [34] or the PDB database [35] to search for the best fitting structural models.
The resulting domain architecture was graphically represented.
The theoretical energetics of the resulting domain interfaces were analysed using the PISA server [ 42].
The resulting domain architecture shows strong similarities across the cA-SR protein family.
We obtained significant hits for all the SEO proteins and designated the resulting domain as 'potential thioredoxin fold'.
We applied a P-value cut-off of 0.01 to the resulting domain predictions and counted the number of protein predictions which were assigned domains.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com