Exact(1)
While NICE makes a recommendation regarding reimbursement based on the (combined) appraisal of clinical and cost-effectiveness, G-BA/IQWiG quantify the additional benefit and its results certainty (e.g. proof, indication, or hint of additional benefit).
Similar(59)
({S}_mathrm{2b} = G_mathrm{ce} =) resulting certainty degree.
A generic solution strategy for the resulting certainty equivalent is presented.
As seen from the perspective of IQWiG, RCTs that combine generalisability and high result certainty are feasible and desirable (Section 1.2.6 IQWiG GM 4.0).
Part of the benefit assessment is to evaluate the actual effects of interventions with the highest possible level of result certainty.
If the evidence provided is not deemed sufficient, e.g. because of poor result certainty or doubts regarding the safety or appropriateness, G-BA can demand additional evidence as part of its decision (§ 35b par. 2 SGB V).
If the compensation is subject to wage taxation, the agent receives a net income equal to ((1-tau _w)s) and the resulting certainty equivalent is begin{aligned} CE_tau (cdot )= 1-tau _w)E[s]-(1-tau _w)^2frac{alpha }{2}mathrm{Var}[s]-frac{1}{2}a^2.
Fig. 7 shows the resulting certainties for both of the S-MCE and GISPEX approaches based on the belief function.
Since DST is able to unravel certainties of results we applied it in a spatially explicit manner to visualize the resulting certainties of the different approaches as discussed in Section 4.2.
Although random sampling can only ensure that a result is correct with a given probability (based on the size of the work, the number of samples and the percentage of the work that is corrupted), it can identify wrong results with certainty and deliver very useful information to a reputation mechanism.
But you can hardly call the results a certainty -- on either side of the debate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com