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Further, we outline how the various consolidation methods find different descriptions of the resulting pathway concepts related to the supplied resultant gene list.
The significant sub-networks (p<0.05) were mapped on the Atlas of Signaling and the resulting pathway is shown on Figure 4.
The "Pathway Prediction" tab, which is another tool that can be found in the "Tools" window, reconstructs the pathway from given multi-FASTA amino acid files and draws the resulting pathway map accompanied by corresponding e-values.
The resulting pathway differed from the known pathway in significant features.
The resulting pathway comprises 86 genes and the interactions between them.
After a manual pathway curation, the resulting pathway was further validated to certify the accuracy of the reconstruction.
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The resulting pathways must contain internal logics and consider the applicable sub-technologies.
Properties of the metabolic network representation can be used to guide and constrain the search problem and rank the resulting pathways.
In a nutshell, it consists of two parts: first, finding the pathways according to the difference in value among the neighboring pixels and second, applying a 1D wavelet transform along the resulting pathways.
Following detailed manual annotation, the resulting pathways were ranked according to the number of contributing melanomas and to the number of SCNA-genes involved in the pathway.
For this reason, the resulting pathways can be interpreted objectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com