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The promise of atherectomy is to avoid the "barotraumas" defined as complications of traditional angioplasty such as dissection, elastic recoil, and disruption of the internal elastic lamina resulting in overwhelming neointima and smooth muscle cell proliferation.
They have also slow-walked numerous nominees, subjecting them to hundreds of questions before granting a vote -- usually resulting in overwhelming confirmation.
Of note in this study is the fact that two of the subjects who died had DFU characterized by ascending gangrene resulting in overwhelming sepsis.
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Humanitarian emergencies occur in situations of conflict, war or civil disturbance, natural disasters, food insecurity or other crises resulting in disruptions that overwhelm national capacities and require international assistance [ 1].
Eventually, the macrophages and immune defenses become overwhelmed, resulting in leishmaniasis.
The long delay is indicative of another problem highlighted in the Syracuse study: the system is overwhelmed, resulting in a significant backlog of cases.
The extent of free radical production following ischemia/reperfusion is so large that protective cellular antioxidant mechanisms are overwhelmed, resulting in peroxidation of lipids, proteins, and nucleic acids [27].
The normal heart possesses substantial ability to neutralize ROS; however, in the injured heart, the antioxidant defence is overwhelmed, resulting in the generation of oxygen-related free radicals.
Because myeloma patients often have irreversible impairment in renal function and increased renal tubular calcium reabsorption, the capacity of the kidneys to clear excess calcium load from the circulation effectively is overwhelmed, resulting in elevated serum calcium levels.
In the presence of an inflammatory reaction, the compensatory mechanism likely becomes overwhelmed, resulting in greater susceptibility to barrier disruption and flooding of the alveolar space with protein-containing fluid.
Cerebral blood flow is found to increase in order to cope with hypermetabolism of glucose, thus resulting in buildup of lactate, thus overwhelming the normal glycolysis and tricarboxylic acid (TCA) cycle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com