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Although a complete breakdown of the blood brain barrier is not evident in ALF, increased permeation to water and other small molecules such as ammonia has been demonstrated resulting from subtle alterations in the protein composition of paracellular tight junctions [37].
Long-term morbidity might be resulting from subtle nutritional insults to the brain in utero.
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Additional modeling scenarios indicated that bloom scenarios resulted from subtle (yet complementary) changes in environmental conditions, and that nutrient enrichment and warming sea surface temperatures stimulated Gambierdiscus growth and resulted in higher cell densities.
Previously, some researchers had proposed that walking in circles could result from subtle differences in the strength or length of the two legs that would bias a person to veer toward the left or right.
While pyrite samples were all derived from the same homogenized batch of ground and sieved mineral, the explanation for variability in the reactivity of pyrite was not determined, but hypothesized to have resulted from subtle differences in acid pretreatment conditions that affected the abundance of Fe(III) surface sites.
Alternatively, slightly different results for DosR mutants in vivo may result from subtle variations in experimental methods that emphasize uncharacterized functions of the DosR regulon.
It is possible that the altered catalytic activities of the PEGylated variants resulted from subtle structural perturbations to the enzyme's 3-dimensional fold.
This suggests that modification of prosocial behavior could result from subtle changes within one region of the brain, while changes in multiple regions my produce markedly different changes.
Furthermore, a recent comparative analysis of eight Xanthomonas genomes revealed that host- and tissue-specificity may result from subtle changes in a small number of individual genes in the gum, hrp, xps, xcs or rpf clusters and differences among regulatory targets, secretory substrates or genes for environmental sensing [38].
They suggested that changes in the trunk muscular activity could result from subtle postural adjustments that were developed during the acute phase to avoid pain.
The apparent paradox may result from subtle differences in complicated experimental procedures, or more interestingly, it might reflect different activities that occur in vivo.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com