Secondly, the persistence of GTS symptoms in adulthood was suggested to result from structural alterations affecting cortico-striatal circuits and a failure of compensatory plastic changes (Peterson, 2001; Draganski et al., 2010).
CNVs usually result from structural genomic alterations such as a deletion (loss), a duplication (gain), an insertion (usually a gain) or unbalanced translocations/inversions that may lead to either loss or gain of sequences near the breakpoints [ 12].
Although increased chamber stiffness usually is thought to result from structural myocardial alterations such as hypertrophy, fibrosis, and modifications of the extracellular matrix, it is often due to myocardial relaxation abnormalities secondary to energy restraints from acute hypoxemia, ischemia, or metabolic stress [ 29].
Apart from structural alterations, endocrine adaptations are important in a mechanistic sense to explain the consequences of perinatal programming.
Check out these 10 ways, from structural alterations to decorative touches, to improve how you can both capture and reflect light in a hall of any size.
For Coates, black men's incarceration rates result from structural racism.
To prioritize alterations for functional study, we used two points of rationale: A) Because the phenotype in question is structural genomic rearrangements, genomic deletions (such as CHD1 and MAP3K7) could be causative or consequences of this phenotype, since they result from structural rearrangements.
Proteins are shown to be affected by the filtration which would result in structural alterations of the proteins that lead to their subsequent aggregation and inactivation [28] [33].
It remains, however, unknown whether these changes could result in structural alterations of the retina or only in functional deficits.
Furthermore, to fully understand the changes in genomic activity resulting from the established structural alterations, it is important to note that the transcriptional status of an individual gene is not always determined by its nuclear location and the degree of local chromatin condensation.
It has been demonstrated previously that disruption of these attachments, via addition of neutralising antibodies or peptides, can induce cells to detach from the ECM resulting in apoptosis, structural alterations and cellular dysfunction.
