Most investigations suffer from methodological flaws such as inadequate study design, poor reporting of results, small sample size, and publication without appropriate peer review process.
The E.P.A. found that all seventeen atrazine studies, including Hayes's, suffered from methodological flaws — contamination of controls, variability in measurement end points, poor animal husbandry — and asked Syngenta to fund a comprehensive experiment that would produce more definitive results.
These studies also suffer from methodological flaws.
We could not further determine associations of treatment effects with potential biases derived from methodological flaws.
These studies suffered from methodological flaws and included a heterogeneous population of ICU patients, including those with sepsis.
Many of the studies in the current literature suffer from methodological flaws in the CSF handling that may be limiting the effectiveness of the technology for this application.
In meta-epidemiological research, researchers often assume that bias (from methodological flaws) in clinical trials is associated with an exaggerated effect of treatment.
Most of these RCTs suffered from methodological flaws, with their study designs and analyses failing to allow for effects of clustering [ 71, 72].
The wide range may result from methodological differences.
Despite the extensive use of statistical analysis, it is still a subject which is often not conceptually well understood, resulting in clear methodological flaws and inadequate reporting in many papers.
Other CAM therapies have either been evaluated in only one RCT with positive results (Chlorella, biofeedback, relaxation), in multiple RCTs with mixed results (magnet therapies), or have positive results from studies with methodological flaws (homeopathy, botanical oils, balneotherapy, anthocyanidins, dietary modifications).
