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The refined model of the target resulted from iterative application of density modification with DM and RESOLVE, interactive model building with COOT [26], coordinate and B-factor refinement with REFMAC [27] and PHENIX [28], and geometry validation with MOLPROBITY [29].
It's a result of iterative modifications developed in the course of almost two centuries.
In Table 1, we compile a list of histone modifications, including the 'writers' and 'erasers' of the modifications and the chromatin conformations resulting from the modifications.
I cannot guarantee that problems resulting from modifications to the registry can be solved.
Comet parameters included: Trypsin enzyme specificity, semi-digested, allowed 1 missed cleavage, 50 ppm mass tolerance, cysteine modification of 57 Da (resulting from the iodoacetamide) and modifications on methionine of 15.999 Da (oxidation).
Other tonal variations resulted from contextual modifications.
Clonal changes in chromatin may result from epigenetic modifications occurring during lymphocyte differentiation.
Unfortunately, unwanted side reactivity can result from such modifications.
As the resulting clustering from iterative execution of R-MCL could contain several redundant and low-quality clusters, those clusters should be removed.
(Both of these estimates differ strongly from those that result from our iterative estimation procedure, indicating its robustness).
These headings resulted from an iterative process, with several added during the charting process as authors agreed the final list.
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