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FOXO expression leads to G1/S arrest, resulting from increased expression of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1, and downregulation of cyclin D1 (Schmidt et al, 2002; Huang and Tindall, 2007; Zhang et al, 2011).
Further, we suggest this enhanced glucose uptake may be a consequence of increased SLC2A2 gene transcription, resulting from increased expression of FOXA2 a critical downstream effector of metabolic processes and transcription factor known to promote SLC2A2 transcription [ 13].
We found that 17-AAG caused increases in the intracellular choline and PC concentrations, likely resulting from increased expression of the choline transporter SLC44A1 and elevation in the de novo synthesis of PC.
However, one possible explanation is inhibition of agonist activity resulting from increased expression and release of agouti-related peptide, a competitive MC3R antagonist, that is observed with fasting (Hahn et al. 1998; Mizuno & Mobbs 1999; Wilson et al. 1999).
In in vitro experiments, the milieu is carefully controlled to be constant for all the incubations and therefore observed differences can be more easily ascribed to differences in enzyme amounts resulting from increased expression.
CBA administration promotes a persistent inflammatory SKM environment resulting from increased expression of a myriad of genes important for immunological function, inflammatory responses, and ability to combat oxidative stress (data not shown) [ 12, 13].
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Neuropathic pain can arise from hyperexcitability of these sensory neurons, which in turn can result from increased expression and/or function of HNC1 channels.
Examination of the profile of T-cell expression in miR-155 knockout mice show intrinsic bias towards Th2 phenotype which results from increased expression of the Th2 cytokines and the transcription factor, c-maf [ 27,28 ].
Furthermore, knockdown of Hsp27 decreased the nuclear translocation as well as the activity of NF-κB in ALDH + BCSCs, which resulted from increasing expression of IκBα.
It is therefore possible that differential host immune responses such as increased GRO-γ production may result indirectly from increased expression of virulence genes in MRSA.
In principle, such a redistribution might in part result from increased expression of Cse4 in a snf2 mutant.
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