HER2 oncogenic properties are thought to result from increased activation of the signaling cascades downstream of HER2.
In the later stages of this development, cell death has been shown to result from increased activation of caspases, withdrawal of Epo or stimulation of the death receptors Fas (CD95) or TRAIL (for review see [40]).
In conclusion, enhanced mitochondrial respiration associated with high fat may result from increased activation of acyl-CoA dehydrogenases, but is not due to increased mRNA or protein expression.
Moreover, C1INH deficiency is associated with pleiotrophic effects that may impact further upon morbidity, including an enhanced production of autoantibodies, thought to result from increased activation of B cells, which may provide the biological explanation for the reported association of the condition with systemic lupus erythematosus (SLE) 14– 14.
Beta-arrestin-2 inactivates Akt resulting in increased activation of GSK3.
Stimulated macrophages isolated from patients demonstrate increased IL-1β release, suggesting that mutations result in increased activation of caspase-1.
The results from our current report indicate that increased activation of latent TGFβ by TSP1 contributes to the overall activity of exogenous TGFβ during the process of ECM contraction in a three-dimensional culture.
The reduction in ρc has been shown to be due to (i) the lowering of the tungsten silicide Schottky barrier height to p-type SiGe resulting from the energy band gap reduction, and (ii) increased activation of the implanted boron with increased Ge fraction.
The increased activation of SRC detected in tumor cells may therefore result from upstream activated RTKs [10].
Increased activation of pro-coagulant processes occurs in the lung in ARDS and does not result from the systemic activation of coagulation (such as is seen in sepsis) [42],[42].
With the increased activation of renal sympathetic function, increased spillover of noradrenaline ensues, resulting in augmentation of renin secretion from the kidney.
