This preliminary work suggests that intravenously injected VP2 peptide has access to the CNS through low levels of BBB permeability potentially resulting in heightened activation of CNS infiltrating CD8 T cells in this model.
Heightened activation of the NMDA receptor may cause poor sleep architecture, while augmentation of the GABA receptor may improve sleep architecture.
Relative to controls, IBS participants showed heightened activation of the ACC, IC, and ventral medial prefrontal regions, suggesting heightened affective responses to painful visceral stimuli [ 38].
During cardiac hypertrophy and/or heart failure processes, there is sustained heightened activation of the sympathetic nervous system [ 19].
In this case, the expansion of NK cell numbers may result from heightened immune/autoimmune responses most likely mediated through the increased production of homeostatic and growth factors such as cytokines.
The Emory University neuroscientist Gregory Berns found that people who dissent from group wisdom show heightened activation in the amygdala, a small organ in the brain associated with the sting of social rejection.
Cai, D. et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB.
Cai, D. et al. Local and systemic insulin resistance resulting from hepatic activation of IKKβand NF-κB.
No frontal lobe areas showed heightened activation during late blocks relative to early blocks when applying a liberal uncorrected threshold of P<0.01.
Taken together, these results suggest that, although there are increased numbers of Ly6Chigh and Ly6Clow splenic CD11b+F4/8 0+cells in CreLysM Casp8fl/fl mice, these cells do not promote heightened activation and functionality of surrounding cells and in fact are capable of suppressing CD4+ T-cell proliferation on a per-cell basis.
The finding of high CD38 levels positively correlated with Leishmania infection reinforces the idea that leishmaniasis can be a cofactor to of this heightened activation status.
