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Along with the choice of the study design, the matching algorithm used in the current study contributed to diminishing the risk of selection bias resulting from confounding factors between groups.
When there are unmeasured confounders, presumably resulting from confounding by indication, the results of the PERR adjusted hazard ratio and the Cox adjusted hazard ratio should differ.
This introduces the possibility of bias resulting from confounding factors such as experimental or analytical protocols, which may explain why we observed slightly reduced performance in two of three independent validation data sets relative to what would be expected based on training data performance.
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These failures may result from confounding variables and/or unresolved scientific issues that surround dengue, including the replication cycle of DENV in a natural setting, the target cells and reservoir for viral replication in vivo, and the effect of asymptomatic/persistent carriers in the dissemination of dengue.
Within Europe, cross-sectional associations between income inequality and mortality probably result from confounding.
This ratio was less than 1, suggesting that the associations observed in the other analyses could all result from confounding.
We cannot exclude the possibility that the association between FGF23 and smoking resulted from confounding by factors such as other life style differences between smokers and non-smokers.
In particular, we attempt to clarify some of the ambiguities and apparent inconsistencies from previous studies by identifying veteran subgroups of importance and controlling for spurious effects that can result from confounding errors introduced by multiple concurrent exposures.
We report a major reduction in breast cancer soon after high exposure to inorganic arsenic in drinking water commenced in northern Chile, which could not have resulted from confounding.
Reported constant or larger carbon gains following earlier snowmelts are thus likely to result from confounding environmental effects, e.g., earlier snowmelts being associated with environmental conditions that promote ecosystem carbon gain or reduce ecosystem respiration, which compensate for the effects of reduced day length and incident radiation.
Because almost all of these studies are based on traits that are known to vary in frequency geographically and they have invariably used averaged national statistics as their source of controls, it is likely that many of these apparent associations resulted from confounding rather than any true biological effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com