Among these novel agents are hybrid bifunctional drugs, i.e. compounds resulting by conjugation of different drugs or containing the pharmocophores of different drugs.
Though the steric crowding of the α-/β-naphthyl group in N,N/chelating ligand is significant its strong electron withdrawing ability resulting from conjugation, stabilizes the chelated Pd(N,N/) species, rather than resulting in dechelation.
Although both the soluble and immobilized peptides demonstrated membrane disruption capabilities, the latter showed a slower rate of kill, presumably due to reduced diffusivity and flexibility resulting from conjugation to the polymer brush.
Spectroscopic and electrochemical data of the organometallic hydrazones 4 and 5 clearly indicate a mutual donor acceptor electronic influence resulting from conjugation between the end groups through the entire hydrazone backbone.
In many genomes, careful analysis of prophages, the remnants of transposition events, insertions resulting from conjugation, and the resulting pseudogenes is considered an essential part of a manual annotation effort.
Based on previous results, conjugation is the most probable way of plasmid transfer in the B. cereus group [41], [74].
The GSH and NAC conjugates were shown to result from conjugation at the C10 position of B[ a]P-7,8-dione, Figure 8.
One-step oxime ligation of 18F-FBA and EuE-k-Aoa (3.2 μmol) generally resulted in conjugation yields > 98% (n = 4) within 15 min at 60 °C.
A number of cation radicals Py m + ● at the initiation step are also influenced by strongly interacting electrolyte ClO4- anions which result in conjugation of PPy short chain oligomers deposited over ZnO nanorods [53].
Coordinating N-atoms and pyridyl rings in 26 were found to be coplanar (distorted pentagonal bipyramidal geometry of the molecule) which results in conjugation in the entire molecule and is, presumably, responsible for extra stability of the molecule [35].
