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We speculate that initial coculture resulted in coordinated signaling between cells, resulting in morphogenetic factor-mediated stimulation and production of Type II collagen, but rapid phenotype loss upon expansion in DMEM with 10% FBS medium.
In contrast, plating onto hyaluronans and in KM resulted in coordinated growth responses of parenchymal and mesenchymal cells (Fig. 1A).
Our results suggest that hypoxic conditions resulted in coordinated upregulation of HIF-1α and Glut-1 in primary tumors.
In that study, Hartman and colleagues demonstrated that stimulation of TNBC cells with lysophosphatidic acid (LPA), an inducer of inflammatory signaling, resulted in coordinated secretion of IL-8, IL-6, and CXCL1/GRO-α via an EZH2/nuclear factor κ-light-chain-enhancer of activated B cells (NFκB -dependent pathway.
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If successful, it could have two huge benefits: it could help the Medicare system remain solvent as the older population grows, and it could result in coordinated care that emphasizes wellness rather than a fragmented, difficult-to-navigate system based on costly acute care.
For example, both higher-order chromatin structure and local cis-regulatory elements may result in coordinated regulation of neighboring Hox loci [31], [32].
POPCORONA misexpression also results in coordinated changes in expression of genes within a previously described transcriptional network regulating cell differentiation and cell wall biosynthesis, and hormone-related genes associated with fiber differentiation.
They recognize conserved motifs of microorganisms and trigger distinct signaling pathways that result in coordinated cellular changes critical to the immediate innate defense and the generation of adaptive immune response.
Research has shown that implementing structural components does not necessarily result in coordinated care, which requires commitment from all staff groups [ 44].
One possibility is that hormonally triggered transcription factor cascades are involved, which ultimately result in coordinated changes in the transcription of a large number of target genes.
Consequently, mRNAs with sense and antisense Alu elements produce a many-to-many network, where those with the sense elements are prevailingly regulated by those with the antisense elements, resulting in coordinated reaction.
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