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Accordingly, MYC mRNA levels resulted down-regulated after transfection of a synthetic hsa-miR-9* (Figure 4C).
No chr 21 gene resulted down-regulated.
MiR-93 showed slight hypo-expression after 12 months HF diet and resulted down-regulated in HCC.
They were: aristaless related homeobox (ARX), chemokine (C-X-C motif) ligand 14 (CXCL14), G protein-coupled receptor 17 (GPR17), LIM homeobox 2 (LHX2) and prostaglandin D2 synthase (PTGD2S), whose expressions resulted down-regulated in infratentorial tumours and up-regulated in supratentorial ones.
Among genes involved in the ubiquitin-dependent proteolysis, a number of E2-conjugating enzymes (UBE2A, UBE2B, UBE2H), E3-ligases (UBE3A, ITCH, SMURF2, F-box proteins, MIB1) and deubiquitinating enzymes (USP1, USP2, USP8, USP12, USP15, USP28, USP32, USP33, USP34, USP38, USP47) resulted down-regulated.
Among genes contributing to the ubiquitin mediated proteolysis and represented on the array, a number of E2-conjugating enzymes (such as UBE2A, UBE2B, UBE2H) and E3 ligases (such as UBE3A, ITCH, SMURF2, MIB1 and some F-box proteins) resulted down-regulated.
The resulting down-mix is subsequently encoded using a mono SSC encoder.
These genes result down-regulated by let-7 over-expression [ 322].
That would have resulted in down three.
A club could have resulted in down two.
Both lines would have resulted in down two.
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