Suggestions(2)
Exact(3)
Subsequently, the resultant side effects and associated complications lead to dose reduction or even discontinuance of the therapy.
Two main limitations that are associated with CisPt use for cancer patients are the resultant side effects and resistance [ 2– 6].
2 Despite the proven efficacy, enfuvirtide was not established as a routinely used drug because of its application mode as subcutaneous injections twice daily and the resultant side effects predominantly present as cutaneous irritations and painful indurations.
Similar(57)
Our lifestyles are increasingly sedentary, with the resultant side-effect of obesity currently recognized as a major health problem worldwide [ 49, 50].
Studies do show that lower doses may be equally as effective as the standard regimens in preventing seizures for women with severe pre-eclampsia [ 21, 24, 28, 29], with resultant fewer side effects.
Inhibiting PEA3 may also allow for a larger therapeutic window for GSI treatment, enabling the reduction of pharmacological doses or possibly eliminating the need for the GSI if PEA3 is indeed upstream of Notch signaling, thus lowering resultant undesirable side effects such as gastrointestinal toxicity and possibly skin cancer.
As best practice management differs between these two conditions, over-diagnosis of AOM may lead to unnecessary antibiotic prescription with the resultant risk of side effects and community antibiotic resistance [ 7, 12, 15].
Through encapsulation of the cytotoxic agent, they reduce the potential for side effects resultant from free circulating drug (Ranson et al, 1997).
Another more biologically oriented definition of Pharmacometrics is " the branch of science concerned with mathematical models of biology, pharmacology, disease, and physiology used to describe and quantify interactions between xenobiotics and patients, including beneficial effects and side effects resultant from such interfaces".
Our future research will examine the impact of providing patients' PRO-CTCAE results to clinicians prior to the visit on the quality of side effects management and resultant clinical outcomes.
In inflammatory bowel disease patients who shunt thiopurine metabolism towards more toxic and less desirable pathways, allopurinol is proving to be an effective add on therapy with good resultant disease control and less treatment side effects.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com