Sentence examples for result of uncoupling from inspiring English sources

In addition, kd cells exhibited significantly less de novo actin polymerization upon anti-IgM F ab' 2 stimulation (Figure 3D) which could be the result of uncoupling the actin regulatory SKAP-HOM – RIAM complex from coordinated signals through the BCR.

Without PikI, cells are able to move at normal speeds, but gradient sensing is dramatically attenuated as a result of uncoupling of activated Ras from its downstream effectors.

Replication obstacles and stalled forks are signalled by ATR, which detects RPA-covered single-stranded DNA that accumulate as a result of uncoupling of MCM helicases and DNA polymerases (Byun et al. 2005; Zou and Elledge 2003).

High levels of ROS can also be produced as a result of uncoupling, or inhibition, of the photosystem machinery in the chloroplast and during photorespiration [ 48].

Increased CYP activity in phosphine environments may be contributing to the detoxification of secondary metabolites due to phosphine exposure (indirect detoxification), or may be a result of uncoupling oxidase and monooxygenase reactions under increased levels of activated oxygen species.

In some cells this rate is equivalent to the maximum rate of the electron transport chain, but in others there is strong rate-limitation imposed by the supply of substrates to the mitochondria, particularly when ATP levels drop as a secondary result of uncoupling and substrates like glucose and fatty acids cannot be activated to glucose-6-phosphate and fatty acyl CoA.

Taken together, our results underscore the importance of uncoupling error-free versus erroneous recombination intermediate processing pathways during replication, and establish a new paradigm for the role of the DNA damage response in regulating genome integrity by controlling crossover timing.

The first measure is based on the simple enumeration of cell activities that, as an effect of uncoupling, resulted enriched uniquely in the transcriptome or in the translatome DEGs.

Since addition of uncoupler resulted in equal ΔΨmit in both strains, we asked what the consequences of uncoupling would be on mitochondrial oxygen consumption.

Thus, loss of iPLA2-VIA activity reduces mitochondrial membrane potential as a result of mitochondrial uncoupling, which increases with age in the iPLA2-VIA −/− flies.

During prolonged exposure to agonists, β2-adrenergic effects fade as a result of phosphorylation, desensitization, uncoupling from the G-proteins and internalization of the receptors (for review see [1]).